In a clinical perspective, the most effective instruments for noninvasive fat reduction use low frequency ultrasound. Through the generation of compression and depression cycles at appropriate frequency, it causes cavitation phenomena at the fat droplet-watery cytoplasm interface & eventually adipocyte rupture and triglyceride release. Ultrasound can be concentrated in a defined subcutaneous area to produce clinically relevant fat lysis while avoiding any damage to blood vessels, nerves, connective tissue, and the underlying organs. The device for lipo-reductive purposes has been specifically designed to prevent unwanted tissue injury. The ultrasound emitter, was demonstrated to achieve selective adipocyte lysis and clinically relevant reduction of the volume of subcutaneous fat pad, in the absence of significant adverse reactions. It has been shown that adipose cell cavitation induces focal alterations of the plasma membrane and lipid leakage.